Experimental study and mechanism analysis of a pulsed laser cleaning aluminum alloy process.

A pulse laser with a wavelength of 1064 nm and a pulse width of 1 µs was used to experiment on the coating of a 2024 aluminum alloy surface. The removal performance of the pulse laser cleaning coating was explored by a single factor analysis and orthogonally conditions, and the effects of the laser power, scanning speed, and pulse frequency on the quality of laser coating removal were summarized. The mechanisms of pulse laser cleaning the coating were studied. The results show that the three parameters of the laser power, scanning speed, and pulse frequency have different effects on the quality of laser coating removal. Among them, with the increase of the scanning speed and pulse frequency, the quality of laser cleaning first increases and then decreases, respectively. With the increase in laser power, the quality of laser cleaning increases. A good laser cleaning quality can be achieved at the laser power of 16.5 W, a scanning speed of 600 mm/s, and a pulse frequency of 30 kHz. The laser cleaning coating involves a variety of mechanisms such as combustion, explosion, gasification, thermal vibration stripping, and laser plasma impact. The result can provide practical references for a better searching of the paint removal.

Clinical efficacy analysis of butylphthalide combined with urinary kallidinogenase in treating chronic cerebral circulatory insufficiency.

OBJECTIVE: To investigate the clinical effect of butylphthalide combined with urinary kallidinogenase in the treatment of chronic cerebral circulatory insufficiency (CCCI). METHODS: A total of 102 CCCI patients admitted to our hospital from October 2020 to December 2021 were retrospectively enrolled in this study. According to the different therapeutic strategy, the patients were divided into combined group (treated with butylphthalide combined with urinary kallidinogenase, n = 51) and butylphthalide group (treated with butylphthalide, n = 51). Blood flow velocity and cerebral blood flow perfusion before and after treatment between the two groups were compared. The clinical efficacy and adverse events of the two groups were analyzed. RESULTS: After treatment, the effective rate of the combined group was significantly higher than the butylphthalide group (p = .015). Before treatment, the blood flow velocity of middle cerebral artery (MCA), vertebral artery (VA), basilar artery (BA) were comparable (p > .05, respectively), while after treatment, the blood flow velocity of MCA, VA, and BA in combined group were faster than those in butylphthalide group (p < .001, respectively). Before treatment, the relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), relative mean transmit time (rMTT) of the two groups were comparable (p > .05, respectively). After treatment, rCBF and rCBV in combined group were higher than those in butylphthalide group (p < .001, respectively), and rMTT in combined group was lower than that in butylphthalide group (p = .001). The rate of adverse events in the two groups were comparable (p = .558). CONCLUSION: Butylphthalide combined with urinary kallidinogenase can improve the clinical symptoms of CCCI patients, and the effect is promising, which is worthy of clinical application.

A new approach to simultaneously reducing, nitrogen doping and noble metal coating of graphene oxide via active-screen plasma.

Graphene is widely used for various applications, especially after nitrogen doping and incorporation with metal nanoparticles. Herein, a simultaneous approach to reducing, nitrogen doping and noble metals coating of graphene oxide (GO) is reported using an advanced active-screen plasma (ASP) technique. With a noble metal plate added as an extra lid of active screen cage, the corresponding noble metal, mainly or fully in pure metal state, depending on the noble metal type, as well as a minority of Fe and Cr, is deposited on GO with simultaneous reduction and nitrogen doping. The ASP treated GO exhibits varying levels of improvement in electrical property depending on the type of noble metal nanoparticles hybridized with. Specifically, ASP treated GO incorporated with Pt or Au revealed 2-4 orders of magnitude of improvement in electrical property.

Clinical therapeutic effects of gastrodin in combination with betahistine on vertigo: A protocol for systematic review and meta-analysis.

BACKGROUND: Vertigo is a well-known presenting complaint common in the main care offices as well as departments. It is also regarded as a symptom of vestibular dysfunction and has been expressed as a feeling of motion, specifically rotational motion. As patients grow older, vertigo also becomes a commonly presenting complaint. The current study will carry out a widespread systematic review to estimate clinical therapeutic effects of gastrodin in combination with betahistine on vertigo. METHODS: We will systematically search different databases, including PubMed, EMBASE, Web of Science, the Cochrane Library, Chinese BioMedical Literature Database (CBM), China National Knowledge Infrastructure Database (CNKI), and WanFang to collect the randomised controlled studies that evaluate the efficiency of gastrodin and betahistine in treating patients with vertigo from their inception to November 2020. However, only studies in English or Chinese will be included. Two authors will independently perform selection, data extraction, and assessment of risk of bias for the included papers. Accordingly, any disagreements between the independent authors will be addressed via discussion or by consulting a third author when needful. Additionally, we will use RevMan 5.3 software to perform the data synthesis. RESULTS: The efficiency of gastrodin and betahistine in treating patients with vertigo will be systematically evaluated. CONCLUSIONS: The current study aims to stipulate more consistent substantiation to explore whether gastrodin combined with betahistine is more effective for the treatment of vertigo. REGISTRATION NUMBER: DOI 10.17605/OSF.IO/HQTZA (https://osf.io/hqtza/).

Surface integrity control of laser cleaning of an aluminum alloy surface paint layer.

Removal of a paint layer of 2024 aluminum alloy was studied using a nanosecond fiber pulsed laser with a maximum power of 30 W and the influence of laser cleaning energy density on the surface integrity of the substrate was explored. The cleaning energy density threshold of the paint layer is 17.69J/cm2 and the damage energy density threshold is 24.77J/cm2. The optimum cleanliness and surface integrity of laser cleaning were obtained when the energy density was 21.23J/cm2. Microhardness and Young's modulus of the surface after laser cleaning were improved by 6% and 25%, respectively. The mechanical properties of the surface of the substrate after laser cleaning were significantly improved, which is an advantage for this high-quality non-destructive cleaning technology of the aircraft skin surface paint layer.

Ipilimumab affectsTlymphocytesandBcl-2mRNAexpression in xenograft tissues of lung cancer-bearing mice by inhibiting TGF-β1/ERK signaling pathway / 中国肿瘤生物治疗杂志

@# Objective: To study the effect of ipilimumab on T lymphocytes and Bcl-2 mRNA expression in lung cancer-bearing mice by inhibiting TGF-β1/ERK signaling pathway. Methods: Forty-five C57 mices inoculated with Lewis lung cancer cells were randomly divided into control group, low dose ipilimumab group and high dose ipilimumab group with 15 mice in each. The low and high dose groups were given 3 mg/kg and 5 mg/kg ipilimumab respectively, while the control group was given 0.9% sodium chloride solution with the same volume. The effects of ipilimumab on TGF-β1/ERK signaling pathway, Bcl-2 mRNA expression, immune function improvement and tumor inhibition in three groups were detected by WB and qPCR. Results: After administration of ipilimumab, the tumor weight and volume of mice in low-dose and high-dose groups were significantly lower than that of the control group, and the tumor inhibition rate increased in a dose-dependent manner (P<0.05). The thymus index and spleen index of mice were significantly higher than that of control group, which also increased in a dose-dependent manner (P<0.05). The levels of CD3+, CD4+, CD4+/CD8+ cells in the high and low dose groups were significantly higher than those in the control group, with significantly higher levels in high dose group compared with the low dose group (P<0.05). The levels of serum inflammatory factors were significantly lower than those in control group, and the levels of serum TNF-α, IL-6 and IL-3 in the high dose group were significantly lower than those in the low dose group (P<0.05). The expressions of TGF-β1, ERK1/2, p-ERK1/2 and MEK in tumor tissues of both high and low dose groups significantly decreased, with more lower levels in high dose group than in low dose groups (all P<0.05), and the positive rate of TGF-β1 expression in high dose group was the lowest. The mRNAexpression of Bcl-2 in tumor tissues of high and low dose groups decreased significantly after drug administration, with a significantly lower level in high does group than that in low dose group (P<0.05). Conclusion: Ipilimumab can effectively inhibit TGF-β1/ERK signaling pathway, improve immune function and down-regulate the expression of Bcl-2, thus inhibit the growth of Lewis lung cancer cells and play an antitumor role in mice.